Survival and late effects of hematopoietic cell transplantation in patients with thalassemia major Research Published on 2022-08-242022-10-05 Journal: Bone marrow transplantation [Category] 바이오마커, [키워드] Affect affected age Allogeneic cell transplantation concerning cumulative cured Diabetes Mellitus diagnosed disorders Effect evaluated female Fertility Follow-up gonadal growth HCT hematological incidence Infection kidney liver long-term survival lung majority male median Mortality Neonate Neonates neurologic obesity osteoarticular Patient patients who survived performance status preserved Psychiatric Retrospective study solid cancer SSC survival thalassemia Thyroid [DOI] 10.1038/s41409-022-01786-4 [Article Type] Research
Paternally expressed gene 3 ( Pw1/Peg3 ) promotes sexual dimorphism in metabolism and behavior친밀하게 발현 된 유전자 3 (PW1/PEG3)은 신진 대사와 행동에서 성 이형성을 촉진합니다Research Article Published on 2022-01-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated Adiposity adulthood age allele alteration Behavior Brain Cell cells Characteristics consequence contribute develop Diabetic Endocrine Epigenetic examined expressed expressing fat accumulation Fatty liver female genomic genomic imprinting gonadal growth hormone insulin insulin resistance life loss of function male mammal mammals manifested masculinization metabolism mice mutant observation parental pathway Peg3 phenotypic postnatal development proliferative promote provide puberty question reduced Regulation selective Sex sex steroid sexual dimorphism Signaling steroid Support tissues weaning [DOI] 10.1371/journal.pgen.1010003 PMC 바로가기 [Article Type] Research Article
Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injuryArticle Published on 2021-12-142022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] ACE-2 addition age Alter analyzed angiotensin-converting enzyme 2 association Cardiology cardiovascular disease Cell clinical study contrary correlation COVID-19 disease Diseases explain expression female gonadal hormone immunology immunostaining independent indicate Injury kidney liver lower expression Lung alveoli lung tissue Medical research men mice Molecular medicine Mouse models murine model myocardial injury protease Protein protein expression regulated respiratory tract SARS-CoV-2 virus serine 2 Sex Sex difference Sex hormones sinusoids the SARS-CoV-2 transmembrane variety of tissue [DOI] 10.1038/s41598-021-03181-3 PMC 바로가기 [Article Type] Article
Candidate genes of SARS-CoV-2 gender susceptibilityArticle Published on 2021-11-092022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome ADAM10 Affect analysis Analysis applied association bioinformatics BST2 candidate cascade CCR5 complement Computational biology and bioinformatics coronavirus COVID-19 disease Effect effective ENPEP evaluate expressed GATA1 Gender Genetic genetics gonadal host cell human protein immunology Infection initiated Interaction IRF1 IRF2 likelihood men molecular outcome ovarian pandemic Pathways performed reaction receptor signaling response SARS-CoV-2 SARS-CoV-2 treatment SERPING1 severity of symptoms Sex difference susceptibility target the SARS-CoV-2 tissue TLR4 TLR7 TMPRSS2 Topic understanding Variation women [DOI] 10.1038/s41598-021-01131-7 PMC 바로가기 [Article Type] Article
Coronavirus disease and male fertility: a systematic reviewReview Published on 2021-08-162022-10-29 Journal: Middle East Fertility Society Journal [Category] COVID-19, [키워드] ACE2 age analyses Analysis Angiotensin-converting enzyme angiotensin-converting enzyme 2 cells Characteristics Comprehensive coronavirus disease COVID-19 demonstrated determine disease Effect examined experiment expressed expression gonadal information male male fertility pathway protein level reproductive required researcher risk SARS-CoV infection SARS-CoV-2 Semen Sperm subject systematic review Testis the patient the SARS-CoV-2 virus Transmissibility Transmission viral persistence Viral transmission [DOI] 10.1186/s43043-021-00073-4 PMC 바로가기 [Article Type] Review
Spectrum of Endocrine Dysfunction and Association With Disease Severity in Patients With COVID-19: Insights From a Cross-Sectional, Observational StudyObservational Study Published on 2021-07-022022-10-04 Journal: Frontiers in Endocrinology [Category] MERS, 임상, [키워드] ACTH analysed Atypical both groups central hypoadrenalism Comorbidities COVID-19 disease disease severity dysfunction Endocrine endocrine organ endocrinology enrolled euthyroid evaluated gonadal greater Hormones hypogonadism insight marker Mild mixed thyroid dysfunction oxygen saturation Patient patients with COVID-19 Prevalence prevalent Result severe disease Severity of disease significant difference Spectrum stratified syndrome those with comorbidities Thyroid Thyroiditis TSH [DOI] 10.3389/fendo.2021.645787 PMC 바로가기 [Article Type] Observational Study
Role of SARS-CoV-2 in Altering the RNA-Binding Protein and miRNA-Directed Post-Transcriptional Regulatory Networks in HumansArticle Published on 2020-09-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] abundantly expressed alteration Altering Analysis analyzed caused characterized computational analysis contribute contributed Coronaviruses COVID-19 COVID-19 pandemic dataset differentially expressed gene dissect dysregulated dysregulation enrichment analysis event ExoN expressed functional Genes genomic genomic sequence gonadal Host immune response Human Human genome human tissue human tissues immune cells immune response Interaction lung cell majority micro-RNA miRs mock-treated modulate motif network novel coronavirus SARS-CoV-2 outbreak outcome performed post-transcriptional regulation progression Protein provided public health emergency RBPs Regulation regulatory network responsible RNA role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell Signaling the SARS-CoV-2 genome tissue viral infection [DOI] 10.3390/ijms21197090 PMC 바로가기 [Article Type] Article